Vitamin B1 deficiency(THIAMINE)

Think of "ATP"
"A"lpha ketoglucoronate dehydrogenase
"T"ransketolase(HMP shunt)
"P"yruvate DH

deficiency causes:(malnutrition/alchoholism)
1.wet-beri beri(cardio)
2. dry beri beri
3. wernicke korsakoff syndrome

How to dx?
high rbc transketolase activity following vit B1 administration.